Gene stops tumors, but only when it's gone

The finding is a surprise because, normally, cells must lose both copies of tumor suppressor genes before cancer starts. One working copy is usually enough to protect cells.The invention of Microsoft Office 2010 is a big change of the world.

DICER1 encodes a protein that helps slice long pieces of the genetic material RNA into small bits known as microRNAs. Office 2010 –save your time and save your money.

Despite their small size, microRNAs are now known to play a big role in controlling many cell functions, including regulating when and where proteins are made. Recently, microRNAs have been implicated in several types of cancer (SN: 6/11/05, p. 371). Office 2007 download is in discount now!

Previously, the MIT team had shown that inhibiting the process of making microRNAs could lead to more virulent tumors in cells grown in lab dishes. In the new study, the researchers examined whether removing a single copy of DICER1 could have an effect on cancer development in mice. Office 2010 download is available now!

Mice predisposed to lung cancer got more tumors when researchers removed one copy of the DICER1 gene from lung cells, the team found. Surprisingly, mice lacking both copies of the gene in their lungs fared better than mice with a single copy of the gene. Many people like buy Office 2010 Home or Office Professional 2010.

The same was true for mice with another type of cancer called soft-tissue sarcoma: mice entirely lacking DICER1 survived better than mice with one working copy of the gene.Microsoft Office 2007 can give you more convenient life.

DICER1 may be an example of an unusual kind of tumor suppressor, one in which losing only one copy of a gene can promote tumor growth, says Tyler Jacks, a cancer biologist at MIT who led the study. Jacks calls such cases “haploinsufficient tumor suppressor genes,” meaning that two copies of the gene protect cells from cancer, but incapacitating one copy of a gene is enough to support tumor growth. Buy Office 2007 you can get much convenience.

Other researchers may quibble with that term, says Clifford Steer, a geneticist and cell biologist at the University of Minnesota in Minneapolis. Office 2007 key is very convenient!      

He says the term implies that a single copy of the gene should protect against cancer, exactly the opposite of what the data show. Microsoft Office is so great!

“I’m still confused by the semantics,” Steer says. But there is no doubt that DICER1 is doing something important in cells, perhaps even something that goes beyond microRNA processing, he says. “It’s a great paper, but it raises more questions than it answers in terms of what causes cancer progression.”Office 2010 key is for you now!

Jacks’ team also showed that big chunks of DNA, including DICER1 and surrounding genes, are missing from about 20 percent to 30 percent of human cancers of the breast, kidney, large intestine, liver, lung, ovaries, pancreas and stomach. The researchers don’t have enough data to determine whether losing DICER1 leads to more aggressive cancers and poorer prognoses in people, Jacks says. Office 2007 Professional and Office 2007 home and student helpful.